Relative Roles of Listeriolysin O, InlA, and InlB in Listeria monocytogenes Uptake by Host Cells-Reference-Cited by-同舟云学术

Relative Roles of Listeriolysin O, InlA, and InlB in Listeria monocytogenes Uptake by Host Cells

Published:2018-10 Issue:10 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Phelps Christopher C.¹²,Vadia Stephen¹²,Arnett Eusondia¹²,Tan Yubo³,Zhang Xiaoli³,Pathak-Sharma Sarika¹,Gavrilin Mikhail A.⁴,Seveau Stephanie¹²⁵

Affiliation:

1. Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA

2. Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

3. Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA

4. Pulmonary, Allergy, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA

5. Infectious Disease Institute, The Ohio State University, Columbus, Ohio, USA

Abstract

Listeria monocytogenes is a facultative intracellular pathogen that infects a wide variety of cells, causing the life-threatening disease listeriosis. L. monocytogenes virulence factors include two surface invasins, InlA and InlB, known to promote bacterial uptake by host cells, and the secreted pore-forming toxin listeriolysin O (LLO), which disrupts the phagosome to allow bacterial proliferation in the cytosol.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00555-18

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