Molecular Requirement for Sterols in Herpes Simplex Virus Entry and Infectivity-Reference-Cited by-同舟云学术

Molecular Requirement for Sterols in Herpes Simplex Virus Entry and Infectivity

Published:2014-12 Issue:23 Volume:88 Page:13918-13922
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wudiri George A.¹²,Pritchard Suzanne M.¹,Li Hong¹³,Liu Jin⁴,Aguilar Hector C.²,Gilk Stacey D.⁵,Nicola Anthony V.¹

Affiliation:

1. Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA

2. Paul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, USA

3. Animal Disease Research Unit, USDA Agricultural Research Service, Washington State University, Pullman, Washington, USA

4. School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, USA

5. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA

Abstract

ABSTRACT Herpes simplex virus 1 (HSV-1) required cholesterol or desmosterol for virion-induced membrane fusion. HSV successfully entered DHCR24 −/− cells, which lack a desmosterol-to-cholesterol conversion enzyme, indicating that entry can occur independently of cholesterol. Depletion of desmosterol from these cells resulted in diminished HSV-1 entry, suggesting a general sterol requirement for HSV-1 entry and that desmosterol can operate in virus entry. Cholesterol functioned more effectively than desmosterol, suggesting that the hydrocarbon tail of cholesterol influences viral entry.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01615-14

Reference27 articles.

1. V 3-integrin routes herpes simplex virus to an entry pathway dependent on cholesterol-rich lipid rafts and dynamin2

2. Specific Association of Glycoprotein B with Lipid Rafts during Herpes Simplex Virus Entry

3. Entry Pathways of Herpes Simplex Virus Type 1 into Human Keratinocytes Are Dynamin- and Cholesterol-Dependent

4. V 3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts

5. Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae.

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