Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2

Author:

Wang Xinxin1,Wen Zhiyuan1,Cao Huizhen1,Luo Jie1,Shuai Lei1,Wang Chong1,Ge Jinying1,Wang Xijun1,Bu Zhigao1ORCID,Wang Jinliang1ORCID

Affiliation:

1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China

Abstract

We previously found that metabotropic glutamate receptor subtype 2 (mGluR2) is an entry receptor for RABV in vitro , and an important internalization factor for SARS-CoV-2 in vitro and in vivo . However, whether mGluR2 is required for RABV infection in vivo was unknown.

Funder

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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