Affiliation:
1. Unité de Recherche sur les Hépatites, le SIDA et les Rétrovirus Humains, Institut National de la Santé et de la Recherche Médicale U 271, Lyon, France.
Abstract
The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally. However, in both cases this inhibitory effect was transient.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference21 articles.
1. Serum a-fetoprotein levels in human disease: perspective from a highly specific monoclonal radioimmunoassay;Bellet D. H.;Proc. Natl. Acad. Sci. USA,1984
2. Comparative study of DHBV DNA levels and endogenous DNA polymerase activity in naturally infected ducklings in France;Cova L.;J. Virol. Methods,1985
3. Dooley J. S. G. L. Davis M. Peters J. G. Waggoner Z. NOTES 475
4. Goodman and J. H. Hoofnagle. 1986. Pilot study of recombinant
5. human a interferon for chronic type B hepatitis. Gastroenterol