DNA Vaccination with the Human Immunodeficiency Virus Type 1 SF162ΔV2 Envelope Elicits Immune Responses That Offer Partial Protection from Simian/Human Immunodeficiency Virus Infection to CD8 + T-Cell-Depleted Rhesus Macaques-Reference-Cited by-同舟云学术

DNA Vaccination with the Human Immunodeficiency Virus Type 1 SF162ΔV2 Envelope Elicits Immune Responses That Offer Partial Protection from Simian/Human Immunodeficiency Virus Infection to CD8 + T-Cell-Depleted Rhesus Macaques

Published:2001-02 Issue:3 Volume:75 Page:1547-1550
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Cherpelis S.¹,Shrivastava I.²,Gettie A.¹³,Jin X.¹,Ho D. D.¹,Barnett S. W.²,Stamatatos L.¹

Affiliation:

1. Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10021-63991;

2. Chiron Corporation, Emeryville, California 94608-29162; and

3. Tulane Regional Primate Research Center, Covington, Louisiana 704333

Abstract

ABSTRACT DNA immunization of macaques with the SF162ΔV2 envelope elicited lymphoproliferative responses and potent neutralizing antibodies. The animals were depleted of their CD8 + T lymphocytes and then challenged intravenously with SHIV162P4. Compared to unvaccinated animals, the vaccinated macaques had lower peak viremia levels, rapidly cleared plasma virus, and showed delayed seroconversion.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.3.1547-1550.2001

Reference22 articles.

1. An HIV type 2 DNA vaccine induces cross-reactive immune responses against HIV type 2 and SIV;Agadjanyan M. G.;AIDS Res. Hum. Retrovir.,1997

2. Prime-boost immunization strategies against HIV;Barnett S. W.;AID Res. Hum. Retrovir.,1998

3. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination;Boyer J. D.;Nat. Med.,1997

4. In vivo protective anti-HIV immune responses in non-human primates through DNA immunization;Boyer J. D.;J. Med. Primatol.,1996

5. Effect of intron A from human cytomegalovirus (Towne) immediate-early gene on heterologous expression in mammalian cells;Chapman B. S.;Nucleic Acids Res.,1991

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