Genome Sequence of Bovine Herpesvirus 4, a Bovine Rhadinovirus, and Identification of an Origin of DNA Replication-Reference-Cited by-同舟云学术

Genome Sequence of Bovine Herpesvirus 4, a Bovine Rhadinovirus, and Identification of an Origin of DNA Replication

Published:2001-02 Issue:3 Volume:75 Page:1186-1194
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zimmermann Wolfgang¹,Broll Hermann²,Ehlers Bernhard³,Buhk Hans-Jörg²,Rosenthal André¹,Goltz Michael³

Affiliation:

1. Department of Genetic Analysis, Genome Sequencing Centre, Institut für Molekulare Biotechnologie, 07745 Jena,1 and

2. Centre for Gene Technology2 and

3. Project P24, Xenotransplantation,3 Robert Koch-Institut, 13353 Berlin, Germany

Abstract

ABSTRACT Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus of cattle. The complete long unique coding region (LUR) of BoHV-4 strain 66-p-347 was determined by a shotgun approach. Together with the previously published noncoding terminal repeats, the entire genome sequence of BoHV-4 is now available. The LUR consists of 108,873 bp with an overall G+C content of 41.4%. At least 79 open reading frames (ORFs) are present in this coding region, 17 of them unique to BoHV-4. In contrast to herpesvirus saimiri and human herpesvirus 8, BoHV-4 has a reduced set of ORFs homologous to cellular genes. Gene arrangement as well as phylogenetic analysis confirmed that BoHV-4 is a member of the genus Rhadinovirus . In addition, an origin of replication ( ori ) in the genome of BoHV-4 was identified by Dpn I assays. A minimum of 1.69 kbp located between ORFs 69 and 71 was sufficient to act as a cis signal for replication.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.3.1186-1194.2001

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