Artemisinins Inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense In Vitro Growth-Reference-Cited by-同舟云学术

Artemisinins Inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense In Vitro Growth

Published:2007-05 Issue:5 Volume:51 Page:1852-1854
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mishina Yuliya V.¹,Krishna Sanjeev²,Haynes Richard K.³,Meade John C.¹

Affiliation:

1. Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi

2. Division of Cellular and Molecular Medicine, Centre for Infection, St George's, University of London, Cranmer Terrace, London, United Kingdom

3. Department of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, People's Republic of China

Abstract

ABSTRACT Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01544-06

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