Vibrio cholerae Virulence Activator ToxR Regulates Manganese Transport and Resistance to Reactive Oxygen Species-Reference-Cited by-同舟云学术

Vibrio cholerae Virulence Activator ToxR Regulates Manganese Transport and Resistance to Reactive Oxygen Species

Published:2020-02-20 Issue:3 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Jiang Hang-hang¹²³,Zhou Yitian³,Liu Ming⁴,Larios-Valencia Jessie³,Lee Zachariah³,Wang Hui⁴^ORCID,Gao Xing-Hua²,Zhu Jun³^ORCID

Affiliation:

1. Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, China

2. Department of Dermatology & Key Lab of Dermatology, Ministry of Education and Public Health, National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, The First Hospital of China Medical University, Shenyang, China

3. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

4. Department of Microbiology, Nanjing Agricultural University, Nanjing, China

Abstract

Like many other pathogens, Vibrio cholerae , the causative agent of cholera, can modulate its gene expression to combat stresses encountered in both aquatic and host environments, including stress posed by reactive oxygen species (ROS). We previously reported that the virulence activator AphB in V. cholerae is involved in ROS resistance. In this study, we found that another key virulence regulator, ToxR, was important for V. cholerae resistance to hydrogen peroxide.

Funder

National Key Basic Research Program

Natural Science Fundation of Jiangsu Province

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00944-19

Reference40 articles.

1. Epidemiology, Genetics, and Ecology of Toxigenic Vibrio cholerae