Expression of HIV-1 Intron-Containing RNA in Microglia Induces Inflammatory Responses-Reference-Cited by-同舟云学术

Expression of HIV-1 Intron-Containing RNA in Microglia Induces Inflammatory Responses

Published:2021-02-10 Issue:5 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Akiyama Hisashi¹^ORCID,Jalloh Sallieu¹,Park Seonmi²,Lei Maohua¹,Mostoslavsky Gustavo²,Gummuluru Suryaram¹^ORCID

Affiliation:

1. Department of Microbiology, Boston University School of Medicine, Boston Massachusetts, USA

2. Center for Regenerative Medicine (CReM), Section of Gastroenterology, Department of Medicine, Boston University School of Medicine, Boston Massachusetts, USA

Abstract

Although peripheral viremia can be effectively suppressed with the advent of highly active antiretroviral therapy, a significant portion of HIV + individuals still suffer from neurocognitive disorders. Despite suppressive therapy, HIV persists in various tissues, including the central nervous system (CNS), leading to chronic inflammation, the chief driver of neurocognitive disorders.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute on Drug Abuse

HHS | NIH | National Institute of Neurological Disorders and Stroke

HHS | NIH | National Institute on Aging

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01386-20

Reference77 articles.