Genetic Suppression of Lethal Mutations in Fatty Acid Biosynthesis Mediated by a Secondary Lipid Synthase-Reference-Cited by-同舟云学术

Genetic Suppression of Lethal Mutations in Fatty Acid Biosynthesis Mediated by a Secondary Lipid Synthase

Published:2021-05-26 Issue:12 Volume:87 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Allemann Marco N.¹²,Allen Eric E.¹²³^ORCID

Affiliation:

1. Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA

2. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA

3. Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA

Abstract

A defining trait among many cultured piezophilic and/or psychrophilic marine Gammaproteobacteria is the incorporation of both monounsaturated and polyunsaturated fatty acids into membrane phospholipids. The biosynthesis of these different classes of fatty acid molecules is linked to two genetically distinct co-occurring pathways that utilize the same pool of intracellular precursors.

Funder

National Science Foundation

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00035-21

Reference63 articles.

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4. The Role of Tandem Acyl Carrier Protein Domains in Polyunsaturated Fatty Acid Biosynthesis

5. Identification of novel protein domains required for the expression of an active dehydratase fragment from a polyunsaturated fatty acid synthase

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