N -(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide Δ4-Desaturase 1-Independent Mechanism-Reference-Cited by-同舟云学术

N -(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide Δ4-Desaturase 1-Independent Mechanism

Published:2021-08-10 Issue:17 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hayashi Yasuhiro¹^ORCID,Tsuchiya Kiyoto²,Yamamoto Mizuki³,Nemoto-Sasaki Yoko¹,Tanigawa Kazunari¹,Hama Kotaro¹,Ueda Yusuke¹,Tanikawa Takashi⁴,Gohda Jin³,Maeda Kenji⁵,Inoue Jun-ichiro⁶,Yamashita Atsushi¹

Affiliation:

1. Faculty of Pharma-Science, Teikyo University, Tokyo, Japan

2. AIDS Clinical Center, National Center for Global Health and Medicine Hospital, Tokyo, Japan

3. Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

4. Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan

5. Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan

6. Senior Professor Office, The University of Tokyo, Tokyo, Japan

Abstract

Sphingolipids could play an important role in SARS-CoV-2 S-mediated membrane fusion with host cells. We studied the cell-cell fusion using SARS-CoV-2 S-expressing cells and sphingolipid-manipulated target cells, with an inhibitor of the sphingolipid metabolism. 4-HPR (also known as fenretinide) is an inhibitor of DES1, and it exhibits antitumor activity and suppresses cell-cell fusion and viral infection. 4-HPR suppresses membrane fusion through a decrease in membrane fluidity, which could possibly be the cause for the inhibition of SARS-CoV-2 infection.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00807-21

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