Targeting Conserved Sequences Circumvents the Evolution of Resistance in a Viral Gene Drive against Human Cytomegalovirus-Reference-Cited by-同舟云学术

Targeting Conserved Sequences Circumvents the Evolution of Resistance in a Viral Gene Drive against Human Cytomegalovirus

Published:2021-07-12 Issue:15 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Walter Marius¹^ORCID,Perrone Rosalba¹,Verdin Eric¹

Affiliation:

1. Buck Institute for Research on Aging, Novato, California, USA

Abstract

The use of defective viruses that interfere with the replication of their infectious parent after coinfecting the same cells—a therapeutic strategy known as viral interference—has recently generated a lot of interest. The CRISPR-based system that we recently reported for herpesviruses represents a novel interfering strategy that causes the conversion of wild-type viruses into new recombinant viruses and drives the native viral population to extinction.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00802-21

Reference53 articles.

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2. Herpesviruses

3. Cloned Defective Interfering Influenza RNA and a Possible Pan-Specific Treatment of Respiratory Virus Diseases

4. Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts

5. Exploiting Genetic Interference for Antiviral Therapy

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