BL-20803, a New, Low-Molecular-Weight Interferon Inducer-Reference-Cited by-同舟云学术

BL-20803, a New, Low-Molecular-Weight Interferon Inducer

Published:1973-06 Issue:6 Volume:3 Page:742-743
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Siminoff Paul¹,Bernard Anthony M.¹,Hursky Valentina S.¹,Price Kenneth E.¹

Affiliation:

1. Department of Microbiology Research, Bristol Laboratories, Syracuse, New York 13201

Abstract

BL-20803 induced interferon in mice when administered via oral or parenteral routes. During multiple dosing with the drug at 48-h intervals, animals exhibited a hyporesponsive state to the third treatment. Inhibition of vaccinia virus infection was correlated with interferon induction.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.3.6.742

Reference8 articles.

1. Circulating interferon in mice after intravenous injection of virus;Baron S.;Science,1963

2. The interferon refractory state: in vivo and in vitro studies of its mechanism;Borden E. C.;J. Immunol.,1971

3. Evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice;Boyle J. J.;Antimicrob. Ag. Chemother.,1967

4. Kinetics of serum interferon response in mice after single and multiple injections of poly I poly C;Buckler C. E.;Proc. Soc. Exp. Biol. Med.,1971

5. Tilorone hydrochloride: mode of action;Mayer G. D.;Science,1970

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