Axenomycins, New Cestocidal Antibiotics

Author:

Bruna C. Della1,Ricciardi M. L.1,Sanfilippo A.1

Affiliation:

1. Farmitalia, Milan, Italy

Abstract

Axenomycins are a new group of macrolide antibiotics isolated from the fermentation broth of Streptomyces lisandri n.sp. They exhibit anthelmintic activity against tapeworms ( Cestoda ). Three different fractions, A, B, and D, have been obtained, the most active fraction being axenomycin D. The activities of the axenomycin complex and axenomycin D against Hymenolepis nana in mice, Taenia pisiformis, Dipylidium caninum , and Diphyllobothrium sp. in dogs, and Moniezia expansa, M. benedeni , and Avitellina centripunctata in lambs were studied in experimentally and naturally infected animals. Axenomycins were effective and well tolerated by the oral route. Worm reduction rates after a single oral dose were 90 to 100% with 5 to 10 mg of axenomycin D/kg and 50 to 100% with 20 mg of axenomycin complex/kg.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference11 articles.

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2. Thaimycins, new anthelmintic and antiprotozoal antibiotics produced by Streptomyces michiganensis var. amylolyticus var. nova;Cassinelli G.;Arch. Mikrobiol.,1970

3. Anthelmintic value of hygromycin B when used in broilers rations and its effect along with certain other drugs on the performance of broilers;Day E. J.;Poultry Sci.,1961

4. Advances in veterinary anthelmintic medication;Gibson T. E.;Advan. Parasitol.,1969

5. Anthelmycin, a new antibiotic with anthelmintic properties;Hamill R. L.;J. Antibiot. (Tokyo) Ser. A,1964

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