Peptide Nucleic Acid Fluorescence In Situ Hybridization-Based Identification of Candida albicans and Its Impact on Mortality and Antifungal Therapy Costs-Reference-Cited by-同舟云学术

Peptide Nucleic Acid Fluorescence In Situ Hybridization-Based Identification of Candida albicans and Its Impact on Mortality and Antifungal Therapy Costs

Published:2006-09 Issue:9 Volume:44 Page:3381-3383
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Forrest G. N.¹,Mankes K.¹,Jabra-Rizk M. A.²³,Weekes E.⁴,Johnson J. K.³,Lincalis D. P.³,Venezia R. A.³

Affiliation:

1. University of Maryland School of Medicine, Division of Infectious Diseases, Baltimore, Maryland 21201

2. University of Maryland School of Dentistry, Baltimore, Maryland 21201

3. University of Maryland School of Medicine, Department of Pathology, Baltimore, Maryland 21201

4. University of Maryland Medical Center, Department of Pharmacy, Baltimore, Maryland 21201

Abstract

ABSTRACT The impact of rapid identification of Candida albicans blood isolates by peptide nucleic acid fluorescence in situ hybridization (PNA FISH) on the selection and expenditure of antifungal therapy was evaluated. PNA FISH was 100% sensitive and specific in the rapid identification of 31 out of 72 candidemias as C. albicans and resulted in a significant reduction of caspofungin usage, with an overall cost savings of $1,729 per patient.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00751-06

Reference12 articles.

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5. Differentiation of Candida albicans and Candida dubliniensis by Fluorescent In Situ Hybridization with Peptide Nucleic Acid Probes

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