APOBEC3F and APOBEC3G mRNA Levels Do Not Correlate with Human Immunodeficiency Virus Type 1 Plasma Viremia or CD4 + T-Cell Count

Author:

Cho Soo-Jin1,Drechsler Henning2,Burke Ryan C.2,Arens Max Q.3,Powderly William2,Davidson Nicholas O.1

Affiliation:

1. Divisions of Gastroenterology

2. Infectious Diseases, Department of Medicine

3. Division of Laboratory Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110

Abstract

ABSTRACT APOBEC3F and APOBEC3G (hA3F and hA3G) are part of an innate mechanism of antiretroviral defense. The human immunodeficiency virus type 1 (HIV-1) accessory protein Vif targets both proteins for proteasomal degradation. Using mRNA from peripheral blood mononuclear cells of 92 HIV-infected subjects not taking antiretroviral therapy and 19 HIV-uninfected controls, we found that hA3F ( P < 0.001) and hA3G ( P = 0.016) mRNA levels were lower in HIV-infected subjects and were positively correlated with one another ( P = 0.003). However, we found no correlation in the abundance of either hA3F or hA3G mRNA with either viral load or CD4 counts in HIV-infected subjects.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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