APOBEC3F and APOBEC3G mRNA Levels Do Not Correlate with Human Immunodeficiency Virus Type 1 Plasma Viremia or CD4 + T-Cell Count-Reference-Cited by-同舟云学术

APOBEC3F and APOBEC3G mRNA Levels Do Not Correlate with Human Immunodeficiency Virus Type 1 Plasma Viremia or CD4 + T-Cell Count

Published:2006-02-15 Issue:4 Volume:80 Page:2069-2072
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Cho Soo-Jin¹,Drechsler Henning²,Burke Ryan C.²,Arens Max Q.³,Powderly William²,Davidson Nicholas O.¹

Affiliation:

1. Divisions of Gastroenterology

2. Infectious Diseases, Department of Medicine

3. Division of Laboratory Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110

Abstract

ABSTRACT APOBEC3F and APOBEC3G (hA3F and hA3G) are part of an innate mechanism of antiretroviral defense. The human immunodeficiency virus type 1 (HIV-1) accessory protein Vif targets both proteins for proteasomal degradation. Using mRNA from peripheral blood mononuclear cells of 92 HIV-infected subjects not taking antiretroviral therapy and 19 HIV-uninfected controls, we found that hA3F ( P < 0.001) and hA3G ( P = 0.016) mRNA levels were lower in HIV-infected subjects and were positively correlated with one another ( P = 0.003). However, we found no correlation in the abundance of either hA3F or hA3G mRNA with either viral load or CD4 counts in HIV-infected subjects.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.80.4.2069-2072.2006

Reference30 articles.

1. Bishop, K. N., R. K. Holmes, A. M. Sheehy, N. O. Davidson, S. J. Cho, and M. H. Malim. 2004. Cytidine deamination of retroviral DNA by diverse APOBEC proteins. Curr. Biol.14:1392-1396.

2. Bonhoeffer, S., G. A. Funk, H. F. Gunthard, M. Fischer, and V. Muller. 2003. Glancing behind virus load variation in HIV-1 infection. Trends Microbiol.11:499-504.

3. Chiu, Y. L., V. B. Soros, J. F. Kreisberg, K. Stopak, W. Yonemoto, and W. C. Greene. 2005. Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells. Nature435:108-114.

4. Conticello, S. G., R. S. Harris, and M. S. Neuberger. 2003. The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. Curr. Biol.13:2009-2013.

5. Doehle, B. P., A. Schafer, and B. R. Cullen. 2005. Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif. Virology339:281-288.

Cited by 62 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The cytidine deaminase APOBEC3G drives cancer mutagenesis and clonal evolution in bladder cancer;2022-09-05

2. APOBEC3, TRIM5α, and BST2 polymorphisms in healthy individuals of various populations with special references to its impact on HIV transmission;Microbial Pathogenesis;2022-01

3. APOBEC3G expression and HIV-1 infection in Burkina Faso;Journal of Public Health in Africa;2018-12-21

4. Genetic and immune determinants of immune activation in HIV-exposed seronegative individuals and their role in protection against HIV infection;Infection, Genetics and Evolution;2018-12

5. APOBEC3G/3A Expression in Human Immunodeficiency Virus Type 1-Infected Individuals Following Initiation of Antiretroviral Therapy Containing Cenicriviroc or Efavirenz;Frontiers in Immunology;2018-08-08