Inactivation of Viruses by Benzalkonium Chloride

Author:

Armstrong J. A.1,Froelich E. J.1

Affiliation:

1. Sterling-Winthrop Research Institute, Rensselaer, New York

Abstract

Benzalkonium chloride (as Roccal or Zephiran) was found to inactivate influenza, measles, canine distemper, rabies, fowl laryngotracheitis, vaccinia, Semliki Forest, feline pneumonitis, meningopneumonitis, and herpes simplex viruses after 10 min of exposure at 30 C or at room temperature. Poliovirus and encephalomyocarditis virus were not inactivated under the same conditions. It was concluded that all viruses tested were sensitive except members of the picorna group. The literature was reviewed.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference18 articles.

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2. Some applications of detergents to the study of the virus of foot-and-mouth disease;CARTWRIGHT S. F.;J. Gen. Microbiol.,1959

3. The effect of temperature, pH, and certain chemicals on egg-cultivated distemper virus;CELIKER A.;Cornell Vet.,1954

4. Studies on the local treatment of rabies-infected wounds;DEAN D. J.;Bull. World Health Organ.,1963

5. Virus och invertsapor;ESPMARK A.;Nord. Med.,1960

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