Identification and some properties of a unique DNA polymerase from cells infected with human B-lymphotropic virus

Author:

Bapat A R1,Bodner A J1,Ting R C1,Cheng Y C1

Affiliation:

1. Department of Pharmacology, University of North Carolina, Chapel Hill 27599-7365.

Abstract

A new DNA polymerase and DNase activity were identified from cells infected with human B-lymphotropic herpesvirus (HBLV). DNA polymerase associated with HBLV infection was similar in its sensitivity to inhibition by ppi analogs as other herpesvirus-specific DNA polymerases but was dissimilar in its inhibition by certain nucleoside triphosphates.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference26 articles.

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3. Ultrastructural characterization of a new human B Iymphotropic DNA virus (human herpesvirus 6) isolated from patients with Iymphoproliferative disease;Biberfeld P.;J. Natl. Cancer Inst.,1987

4. Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs;Cheng Y.;J. Biol. Chem.,1987

5. Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1;Cheng Y.;Proc. Natl. Acad. Sci. USA,1983

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