Affiliation:
1. Department of Pathology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103
Abstract
The in vitro activity of tobramycin was quantitatively compared with that of gentamicin sulfate against 195 bacterial isolates from clinical material. Tobramycin was found to be twice as active as gentamicin against isolates of
Pseudomonas aeruginosa
. Conversely, gentamicin proved fourfold more active than tobramycin against isolates of
Serratia marcescens
. Both drugs were of comparable activity against isolates of
Staphylococcus aureus
and the majority of the enterobacterial isolates other than
S. marcescens
. On the basis of the obtained data, the following criteria are proposed for the interpretation of diffusion susceptibility tests with 10-μg discs of gentamicin and tobramycin.
Enterobacteriaceae
and isolates of
S. aureus
are designated as susceptible to gentamicin and tobramycin if the zones of inhibition measure 15 mm or more in diameter; zones of 14 mm or less are indicative of resistance.
Pseudomonadaceae
are interpreted as sensitive to tobramycin and gentamicin if the inhibition zones measure at least 15 and 12 mm in diameter, respectively.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
14 articles.
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