Pharmacokinetics of DA-7867, a New Oxazolidinone, after Intravenous or Oral Administration to Rats: Intestinal First-Pass Effect-Reference-Cited by-同舟云学术

Pharmacokinetics of DA-7867, a New Oxazolidinone, after Intravenous or Oral Administration to Rats: Intestinal First-Pass Effect

Published:2004-02 Issue:2 Volume:48 Page:659-662
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bae Soo K.¹,Chung Won-Suk¹,Kim Eun J.¹²,Rhee Jae K.²,Kwon Jong W.²,Kim Won B.²,Lee Myung G.¹

Affiliation:

1. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Kwanak-Gu, Seoul 151-742

2. Research Laboratory, Dong-A Pharmaceutical Company, Ltd., Yongin, Kyunggi-Do 449-900, Korea

Abstract

ABSTRACT Pharmacokinetic parameters of DA-7867 were dose independent after both intravenous administration and oral administration (at doses of 1 to 20 mg/kg of body weight) to rats. After oral administration of DA-7867 to rats at a dose of 10 mg/kg, approximately 8.27% of oral dose was not absorbed from the gastrointestinal tract, F was 70.8%, and approximately 21.8% of the oral dose was eliminated by the intestine (intestinal first-pass effect).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.2.659-662.2004

Reference22 articles.

1. Bae S. K. E. J. Kim J. W. Kwon W. B. Kim and M. G. Lee. 2003. High-performance liquid chromatographic analysis of DA-7867 a new oxazolidinone in human plasma and urine and rat tissue homogenates. J. Chromatogr. B Biomed. Appl. 794: 397-403.

2. Chiou, W. L. 1978. Critical evaluation of potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J. Pharmacokinet. Biopharm.6:539-549.

3. Chiou, W. L. 1979. New calculation method for mean apparent drug volume of distribution and application to rational dosage regimen. J. Pharm. Sci.68:1067-1069.

4. Chiou, W. L. 1980. New calculation method of mean total body clearance of drugs and its application to rational regimens. J. Pharm. Sci.69:90-91.

5. Daniel, J. D., and N. J. Ronald. 2001. Oxazolidinone antibiotics. Lancet358:1975-1982.

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Potential role of tedizolid phosphate in the treatment of acute bacterial skin infections;Drug Design, Development and Therapy;2013-04

2. Solubility-Driven Optimization of (Pyridin-3-yl) Benzoxazinyl-oxazolidinones Leading to a Promising Antibacterial Agent;Journal of Medicinal Chemistry;2013-03-13

3. The oxazolidinones: past, present, and future;Annals of the New York Academy of Sciences;2011-12

4. In vitroandin vivosmall intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences;Drug Metabolism Reviews;2011-08-23

5. Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent;European Journal of Medicinal Chemistry;2011-04