Ribosomal Alterations Contribute to Bacterial Resistance against the Dipeptide Antibiotic TAN 1057-Reference-Cited by-同舟云学术

Ribosomal Alterations Contribute to Bacterial Resistance against the Dipeptide Antibiotic TAN 1057

Published:2004-02 Issue:2 Volume:48 Page:619-622
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Limburg E.¹,Gahlmann R.¹,Kroll H.-P.¹,Beyer D.¹

Affiliation:

1. Department of Antiinfectives, Pharma Research, Bayer Health Care AG, D-42096 Wuppertal, Germany

Abstract

ABSTRACT TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations in the ribosomes contribute to the resistance of the bacteria.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.2.619-622.2004

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