Affiliation:
1. National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata 700 010, India
2. Jissen Women's College, Tokyo, Japan
Abstract
ABSTRACT
Multidrug-resistant strains of
Shigella dysenteriae
type 1 were implicated in three outbreaks and sporadic cases of dysentery in eastern India in 2002 and 2003. After a hiatus of 14 years, this pathogen reemerged with an altered antibiotic resistance pattern. In addition to ampicillin, co-trimoxazole, tetracycline, chloramphenicol, and nalidixic acid, all the recent strains were resistant to norfloxacin, lomefloxacin, pefloxacin, and ofloxacin and showed reduced susceptibility to ciprofloxacin. Pulsed-field gel electrophoresis identified a new clone of
S. dysenteriae
type 1 that was associated with the recent outbreaks and sporadic cases. Based on the spatial and temporal spread of multidrug-resistant
S. dysenteriae
type 1, we predict that this clonal type may spread further in this region.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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