Bifunctional Anti-Human Immunodeficiency Virus Type 1 Small Molecules with Two Novel Mechanisms of Action-Reference-Cited by-同舟云学术

Bifunctional Anti-Human Immunodeficiency Virus Type 1 Small Molecules with Two Novel Mechanisms of Action

Published:2004-02 Issue:2 Volume:48 Page:663-665
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Huang Li¹,Yuan Xiong¹,Aiken Christopher²,Chen Chin Ho¹

Affiliation:

1. Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710

2. Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Abstract

ABSTRACT A class of betulinic acid derivatives was synthesized to target two critical steps in the human immunodeficiency virus type 1 (HIV-1) replication cycle, entry and maturation. Each mechanism of HIV-1 inhibition is distinct from clinically available anti-HIV therapeutics. The viral determinants of the antientry and antimaturation activities are the bridging sheet of HIV-1 gp120 and the P24/p2 cleavage site, respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.2.663-665.2004

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