Affiliation:
1. Department of Medicine, University of Maryland School of Medicine, Baltimore 21201.
Abstract
An attenuated Salmonella typhi Ty21a vaccine was administered to 18 infants and toddlers (less than or equal to 24 months old) to determine its safety and immunogenicity. The vaccination (10(9) CFU per dose, three doses) was well tolerated. However, after the vaccination there was no evidence of a humoral or cellular immune response to S. typhi. The vaccine used was known to be immunogenic for older children and adults. The results support the view that the immunogenicity of Ty21a is age dependent.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference22 articles.
1. Controlled field trial in British Guiana schoolchildren of heatkilled phenolized and acetone-killed Iyophilized typhoid vaccines;Ashcroft M.;Am. J. Hyg.,1969
2. Surface co-expression of Vibrio cholerae and Salmonella typhi 0-antigens on Ty 2la clone EX210;Attridge S. R.;Microb. Pathog.,1990
3. Efficacy of one or two doses of Ty 2la Salmonella typhi vaccine in enteric-coated capsules in a controlled field trial. Chilean Typhoid Committee;Black R. E.;Vaccine,1990
4. Immunogenicity of Ty 2la attenuated Salmonella typhi given with sodium bicarbonate or in enteric-coated capsules;Black R. E.;Biol. Stand.,1983
5. Construction of a potential bivalent vaccine strain: introduction of Shigella sonnei form I antigen genes into the galE Salmonella typhi Ty 2la typhoid vaccine strain;Formal S. B.;Infect. Immun.,1981
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