Expression of Murine Leukemia Virus Envelope Protein Is Sufficient for the Induction of Apoptosis-Reference-Cited by-同舟云学术

Expression of Murine Leukemia Virus Envelope Protein Is Sufficient for the Induction of Apoptosis

Published:2008-03 Issue:5 Volume:82 Page:2586-2589
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhao Xiaoqing¹,Yoshimura Fayth K.¹

Affiliation:

1. Department of Immunology and Microbiology and the Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201

Abstract

ABSTRACT The generation of cytopathic effects by murine leukemia viruses (MLVs) in different cell types correlates with the ability of the virus to induce thymic lymphoma. We showed that the induction of apoptosis in mink epithelial cells by mink cell focus-forming (MCF) MLV infection results in the accumulation of high levels of both unintegrated viral DNA and the envelope precursor polyprotein (gPr80 env ). Comparisons of envelope protein expression levels of plasmid clones of the env gene of the MCF13 and noncytopathic NZB-9 MLV strains demonstrated that the accumulation of MCF13 gPr80 env results in endoplasmic reticulum stress and is sufficient for the induction of apoptosis.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02291-07

Reference36 articles.

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