Three Cases of Infection with Hepatitis C Virus Genotype 5 among Brazilian Hepatitis Patients

Author:

Levi José Eduardo1,Takaoka Deise Tihe1,Garrini Regina Helena1,Fachini Roberta Maria1,Focaccia Roberto2,de Bortholi Santos Edgar2,Mitre Heloisa Pedrosa3,de Mendonça João Silva3,de Paula Cavalheiro Norma4,Barone Antonio Alci4,Wendel Silvano15

Affiliation:

1. Centro de Imunologia e Imunogenética,

2. Instituto de Infectologia Emílio Ribas,

3. Serviço de Moléstias Infecciosas, Hospital do Servidor Público Estadual,

4. Laboratório de Hepatites, Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo

5. Banco de Sangue, Hospital Sírio-Libanês, São Paulo, Brazil

Abstract

ABSTRACT During the course of routine genotyping of hepatitis C virus isolates by 5′ noncoding region sequencing, three samples were found to bear genotype 5-specific nucleotides. A serotyping method was subsequently applied and confirmed the finding. This is the first report of the occurrence of genotype 5 in Brazil.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference13 articles.

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2. Identification of numerous hepatitis C virus genotypes in Montreal, Canada

3. Blatt, L. M., M. G. Mutchnick, M. J. Tong, F. M. Klion, E. Lebovics, B. Freilich, N. Bach, C. Smith, J. Herrera, H. Tobias, A. Conrad, P. Schmid, and J. G. McHutchison. 2000. Assessment of hepatitis C virus RNA and genotype from 6807 patients with chronic hepatitis C in the United States. J. Viral Hepat.7:196-202.

4. Bukh, J., C. L. Apgar, R. Engle, S. Govindarajan, P. A. Hegerich, R. Tellier, D. C. Wong, et al. 1998. Experimental infection of chimpanzees with hepatitis C virus of genotype 5a: genetic analysis of the virus and generation of a standardized challenge pool. J. Infect. Dis.178:1193-1197.

5. Focaccia, R., O. J. G. Conceição, H. Sette, Jr., E. Sabino, L. Bassit, D. R. Nitrini, A. V. Lomar, et al. 1998. Estimated prevalence of viral hepatitis in the general population of the municipality of São Paulo, measured by a serologic survey of a stratified, randomized and residence-based population. Braz. J. Infect. Dis.2:269-284.

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