Affiliation:
1. Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, California, USA
Abstract
Antiapoptotic Bcl-2 inhibitors have been shown to exert potent antiviral activities against various types of viruses via mechanisms that are currently poorly understood. This study has revealed that Bcl-2 inhibitors’ mediation of cell cycle arrest at the G0/G1 phase, rather than their proapoptotic activity, plays a critical role in blocking mammarenavirus multiplication in cultured cells.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology