The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies-Reference-Cited by-同舟云学术

The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies

Published:2022-07-13 Issue:13 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chan Conrad En-Zuo¹²,Ng Ching-Ging¹,Lim Angeline Pei-Chew¹,Seah Shirley Lay-Kheng¹,Chye De-Hoe¹,Wong Steven Ka-Khuen¹,Lim Jie-Hui¹,Lim Vanessa Zi-Yun³,Lai Soak-Kuan³,Wong Pui-San¹,Leong Kok-Mun¹,Liu Yi-Chun¹,Sugrue Richard J.³,Tan Boon-Huan¹³⁴^ORCID

Affiliation:

1. Biological Defence Programme, DSO National Laboratories, Singapore, Republic of Singapore

2. Infectious Disease Laboratory, National Centre for Infectious Diseases, Singapore, Republic of Singapore

3. School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore

4. Infection and Immunity, LKC School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore

Abstract

The SARS-CoV-2 spike (S) protein receptor binding domain (RBD) mediates the attachment of SARS-CoV-2 to the host cell. This interaction plays an essential role in initiating virus infection, and the S protein RBD is therefore a focus of therapeutic and vaccine interventions.

Funder

DSO National Laboratories - Singapore

Nanyang Technological University

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00455-22

Reference58 articles.

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