Affiliation:
1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Abstract
ROCK is a central kinase in cells that regulates numerous cellular functions, including cellular polarity, motility, proliferation, and apoptosis. Here we reveal a novel antiviral activity of ROCK during infection with HCMV, a prevalent pathogen infecting most of the population worldwide. We reveal ROCK1 is translocated to the nucleus, where it mainly localizes to the nucleolus. Our findings suggest that ROCK’s antiviral activity may be related to activation of the actomyosin network and inhibition of capsid egress out of the nucleus.
Funder
European Research Council
Israel Science Foundation
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
9 articles.
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