Cell Culture Studies on the Antiviral Activity of Ether Derivatives of 5-Hydroxymethyldeoxyuridine-Reference-Cited by-同舟云学术

Cell Culture Studies on the Antiviral Activity of Ether Derivatives of 5-Hydroxymethyldeoxyuridine

Published:1974-10 Issue:4 Volume:6 Page:393-396
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Meldrum J. B.¹,Gupta V. S.¹,Saunders J. R.¹

Affiliation:

1. Animal Pathology Division, Health of Animals Branch, Agriculture Canada, Saskatchewan Area Laboratory, and Departments of Veterinary Physiological Sciences Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N OWO, Canada

Abstract

The antiviral activity of several ether derivatives of 5-hydroxymethyldeoxyuridine against the herpesvirus of infectious bovine rhinotracheitis was determined in monolayer cultures of secondary bovine fetal kidney cells. 5-Methoxy-methyldeoxyuridine (OCH 3 UdR) was found to be markedly inhibitory against this virus. Pretreatment of the cells with OCH 3 UdR, simultaneous addition of OCH 3 UdR with virus to the cells, and postinfection treatment with OCH 3 UdR were found to be effective in inhibiting virus-induced cytopathogenic effect. Against this virus, OCH 3 UdR was found to be as potent as 5-iododeoxyuridine and cytosine arabinoside. The α-anomer of OCH 3 UdR did not show antiviral activity. Preliminarly toxicity studies indicate that OCH 3 UdR has a very low acute toxicity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.6.4.393

Reference22 articles.

1. Synthesis of 5-substituted ether derivatives of 5-hydroxymethyldeoxyuridine and their "a-anomers;Bubbar G. L.;Can. J. Chem.,1970

2. Cell culture studies on antiviral agents. 1. Action of cytosine arabinoside and some comparisons with 5-iodo-2'-deoxyuridine;Buthala D. A.;Proc. Soc. Exp. Biol. Med.,1964

3. Clinical studies with systemic administration of antimetabolites of pyrimidine nucleosides in viral infections;Calabresi P.;Ann. N. Y. Acad. Sci.,1965

4. Virus-induced acquisition of metabolic function. I. Enzymatic formation of 5-hydroxymethyldeoxycytidylate;Flaks J. G.;J. Biol. Chem.,1959

5. Immunobiological studies with the virostatics 5-ethyl-2'-droxyuridine (EDU) and 1-ally1-3,5-diethy1-6- chlorouracil (ACIU);Gauri K. K.;Chemotherapy,1969

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Detoxification of DNA hydroperoxide by glutathione transferases and the purification and characterization of glutathione transferases of the rat liver nucleus;Biochemical Journal;1988-09-15

2. Ap endonucleases and dna glycosylases that recognize oxidative dna damage;Environmental Mutagenesis;1988

3. Structure and Conformation of the Antiviral Agent 5-Methoxymethyl-2′-deoxyuridine;Nucleosides and Nucleotides;1986-02

4. 5-Hydroxymethyl Uracil: A Product of Ionizing Radiation and Tritium Transmutation Formed in DNA;Radiation Carcinogenesis and DNA Alterations;1986

5. Quantitative determination of the 5-(hydroxymethyl)uracil moiety in the DNA of .gamma.-irradiated cells;Biochemistry;1985-08-01