Alterations in the MA and NC Domains Modulate Phosphoinositide-Dependent Plasma Membrane Localization of the Rous Sarcoma Virus Gag Protein-Reference-Cited by-同舟云学术

Alterations in the MA and NC Domains Modulate Phosphoinositide-Dependent Plasma Membrane Localization of the Rous Sarcoma Virus Gag Protein

Published:2013-03-15 Issue:6 Volume:87 Page:3609-3615
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Nadaraia-Hoke Shorena¹,Bann Darrin V.¹²,Lochmann Timothy L.¹,Gudleski-O'Regan Nicole³,Parent Leslie J.¹³²

Affiliation:

1. Departments of Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA

2. the MD/PhD Program, Penn State College of Medicine, Hershey, Pennsylvania, USA

3. Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania, USA

Abstract

ABSTRACT Retroviral Gag proteins direct virus particle assembly from the plasma membrane (PM). Phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P 2 ] plays a role in PM targeting of several retroviral Gag proteins. Here we report that depletion of intracellular PI(4,5)P 2 and phosphatidylinositol-(3,4,5)-triphosphate [PI(3,4,5)P 3 ] levels impaired Rous sarcoma virus (RSV) Gag PM localization. Gag mutants deficient in nuclear trafficking were less sensitive to reduction of intracellular PI(4,5)P 2 and PI(3,4,5)P 3 , suggesting a possible connection between Gag nuclear trafficking and phosphoinositide-dependent PM targeting.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.03059-12

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