Affiliation:
1. Institute of Medical Microbiology, University of Uppsala, Uppsala, Sweden
Abstract
Of 137
Staphylococcus aureus
strains, 87 agglutinated in normal rabbit serum. The agglutination was shown to be caused by the Fc-part of immunoglobulin G (IgG). F(ab
1
)
2
-fragments of IgG and immunoglobulin M (IgM) in corresponding concentrations were unreactive. The agglutinating strains had a high or moderate content of protein A. Strains with a low content of protein A and protein A-negative mutants did not agglutinate. The importance of the reaction between the Fc part of IgG and protein A for serotyping of
S. aureus
is demonstrated. Two alternative methods for serotyping
S. aureus
are suggested, using either F(ab
1
)
2
fragments of IgG or intact IgM.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference34 articles.
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