Functional Analysis of Phenazine Biosynthesis Genes in Burkholderia spp.-Reference-Cited by-同舟云学术

Functional Analysis of Phenazine Biosynthesis Genes in Burkholderia spp.

Published:2021-05-11 Issue:11 Volume:87 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Hendry Samuel¹,Steinke Stephan²,Wittstein Kathrin³,Stadler Marc⁴⁵,Harmrolfs Kirsten⁶,Adewunmi Yetunde¹,Sahukhal Gyan¹,Elasri Mohamed¹,Thomashow Linda⁷,Weller David⁷,Mavrodi Olga¹,Blankenfeldt Wulf²³,Mavrodi Dmitri¹^ORCID

Affiliation:

1. Center for Molecular and Cellular Biosciences, School of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, Hattiesburg, Mississippi, USA

2. Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, Germany

3. Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany

4. Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Germany

5. Institute of Microbiology, Technische Universität Braunschweig, Braunschweig, Germany

6. Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

7. Wheat Health, Genetics and Quality Research Unit, USDA Agricultural Research Service, Pullman, Washington, USA

Abstract

Although the production of phenazines in Burkholderia was first reported almost 70 years ago, the role these metabolites play in the biology of these economically important microorganisms remains poorly understood. Our results revealed that the phenazine biosynthetic pathway in Burkholderia has a complex evolutionary history, which likely involved horizontal gene transfers among several distantly related groups of organisms.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.02348-20

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