Author:
Bredt W,Wellek B,Brunner H,Loos M
Abstract
Mycoplasma pneumoniae cells were rounded and killed by fresh guinea pig serum (GPS) which did not contain detectable amounts of antibody. The first component of complement (C1) was bound by M. pneumoniae in considerable amounts from both GPS and purified C1. The C1 bound by the cells was reacting with C4. Sequential addition of C1, C4, C2, and C-ethylenediaminetetraacetate to glass-grown M. pneumoniae cells resulted in rounding of a significant number of cells. M. orale and M. fermentans showed a reduced binding capacity for C1 as compared with M. pneumoniae. Both species were only slowly killed by fresh GPS, whereas M. hominis was as sensitive as M. pneumoniae. The results suggest an antibody-independent interaction between some components of the membrane surface of M. pneumoniae and C1, resulting in an activation of the complement system leading to the killing of the mycoplasma cells.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference16 articles.
1. Role of complement in immune inactivation ofMycoplasma gallisepticum;Barker L. F.;J. Bacteriol.,1967
2. Hemolysin titration based on fixation of the activated first component of complement: evidence that one molecule ofhemolysin suffices to sensitize an erythrocyte;Borsos T.;J. Immunol.,1965
3. Growth morphology of Mycoplasma pneumoniae strain FH on glass surface;Bredt W.;Proc. Soc. Exp. Biol. Med.,1968
4. Interactions between Mycoplasma pneumoniae and guinea pig complement;Bredt W.;Infect. Immun.,1975
5. Measurement of Mycoplasma pneumoniae mycoplasmacidal antibody in human serum;Brunner H.;J. Immunol.,1972
Cited by
44 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献