Abstract
CFW mice given submicrogram doses of endotoxins intravenously became highly susceptible to the lethal effects of 0.5 mg of histamine given intraperitoneally 1 to 2 h later. The histamine-sensitizing effects of the endotoxins were transitory and disappeared within 6 to 8 h. L-Epinephrine administered intravenously immediately after histamine challenge protected mice from death, but aterenol and isoproterenol were ineffective. The histamine-sensitizing effect in endotoxins was precipitated by anti-endotoxin sera with a concomitant eightfold loss in activity. However, dissociation of the immune complex in 0.25 M acetic acid fully restored histamine-sensitizing activity. The transitory nature of the hypersensitivity produced by endotoxin and the high heat resistance of the active material prove that it is different from the histamine-sensitizing effects of pertussigen.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference11 articles.
1. Protection against histamine shock by catecholamines inBordetella pertussis-treated, adrenalectomized or adrenergic blocked mice;Bergman R. K.;Proc. Soc. Exp. Biol. Med.,1966
2. Effects of epinephrine, norepinephrine and isoproterenol against histamine challenge in Bordetella pertussis-treated and (8-adrenergic blocked mice;Bergman R. K.;Life Sci.,1971
3. Kabat E. A. 1961. Kabat and Mayer's experimental immunochemistry 2nd ed. Charles C Thomas Publisher Springfield Ill.
4. Kass E. H. R. P. Atwood and P. J. Porter. 1964. Observations on the locus of lethal action of bacterial endotoxin p. 596-601. In M. Landy and W. Braun (ed.) Bacterial endotoxins. Rutgers University Press New Brunswick N.J.
5. Anaphylactic reactions in mice induced byBordetellapertussis lipopolysaccharide;Malkiel S.;J. Allergy,1964
Cited by
15 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献