Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains-Reference-Cited by-同舟云学术

Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains

Published:2016-11 Issue:11 Volume:60 Page:6916-6919
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Abastabar Mahdi¹,Rahimi Nooshin²,Meis Jacques F.³⁴^ORCID,Aslani Narges²,Khodavaisy Sadegh⁵,Nabili Mojtaba¹,Rezaei-Matehkolaei Ali⁶,Makimura Koichi⁷,Badali Hamid¹⁸^ORCID

Affiliation:

1. Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

2. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

3. Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands

4. Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

5. Department of Medical Mycology and Parasitology, Tehran University of Medical Science, Tehran, Iran

6. Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

7. Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Japan/Asia International Institute of Infectious Diseases Control, Teikyo University, and Teikyo University Institute of Medical Mycology, Tokyo, Japan

8. Department of Medical Mycology and Parasitology, Mazandaran University of Medical Sciences, Sari, Iran

Abstract

ABSTRACT A collection of azole-susceptible ( n = 141) and azole-resistant ( n = 27) Aspergillus fumigatus isolates was tested against seven antifungal drugs, including the new imidazoles lanoconazole and luliconazole. The luliconazole and lanoconazole MIC 90 values for the azole-susceptible strains were 0.001 μg/ml and 0.008 μg/ml, and those for the azole-resistant strains were 0.016 μg/ml and 0.032 μg/ml.

Funder

Mazandaran University of Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01193-16

Reference22 articles.

1. Diagnosis and management of aspergillosis in the Netherlands: a national survey

2. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America

3. Posaconazole after previous antifungal therapy with voriconazole for therapy of invasive aspergillus disease, a retrospective analysis