Affiliation:
1. Department of Medical Specialities, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Abstract
The MICs and minimum fungicidal concentrations of amphotericin B, natamycin, miconazole, itraconazole, and flucytosine against 17 isolates of Fusarium solani, 14 isolates of Fusarium moniliforme, 10 isolates of Fusarium oxysporum, and 3 isolates of Fusarium semitectum were determined by a broth microdilution method. Amphotericin B and natamycin were the most active agents tested and failed to show any inoculum size effect. In contrast, miconazole and itraconazole showed poor inhibitory and fungicidal activities, and the inoculum size had a major effect on the results. Flucytosine had no activity against any of the isolates tested.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference16 articles.
1. The emerging role of Fusarium infections in patients with cancer;Anaissie E.;Medicine,1988
2. Invasive fusarium infections in bone marrow transplant recipients;Blazer R. R.;Am. J. Med.,1984
3. Fusarium species osteomyelitis;Bourguignon R. L.;J. Bone Jt. Surg.,1976
4. Boyle F. T. J. F. Ryley and R. G. Wilson. 1987. In vitro-in vivo correlations with azole antifungals p. 31-41. In R. A. Fromtling (ed.) Recent trends in the discovery development and evaluation of antifungal agents. J. R. Prous Science Publishers S. A.
5. Fusarium solani infection during treatment for acute leukemia;Cho C. T.;J. Pediatr.,1983
Cited by
74 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献