Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals-Reference-Cited by-同舟云学术

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals

Published:2018-08 Issue:8 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wall Richard J.¹,Moniz Sonia¹,Thomas Michael G.¹,Norval Suzanne¹,Ko Eun-Jung¹,Marco Maria²,Miles Timothy J.²,Gilbert Ian H.¹,Horn David¹,Fairlamb Alan H.¹,Wyllie Susan¹

Affiliation:

1. Wellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom

2. Diseases of the Developing World, GlaxoSmithKline, Madrid, Spain

Abstract

The lack of information regarding the mechanisms of action (MoA) or specific molecular targets of phenotypically active compounds can prove a barrier to their development as chemotherapeutic agents. Here, we report the results of our orthogonal genetic, molecular, and biochemical studies to determine the MoA of a novel 7-substituted 8-hydroxy-1,6-naphthyridine (8-HNT) series that displays promising activity against Trypanosoma brucei and Leishmania donovani .

Funder

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00235-18

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