Integron-Derived Aminoglycoside-Sensing Riboswitches Control Aminoglycoside Acetyltransferase Resistance Gene Expression-Reference-Cited by-同舟云学术

Integron-Derived Aminoglycoside-Sensing Riboswitches Control Aminoglycoside Acetyltransferase Resistance Gene Expression

Published:2019-06 Issue:6 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wang Shasha¹²,He Weizhi¹²,Sun Wenxia¹²,Zhang Jun¹²,Chang Yaowen¹²,Chen Dongrong¹²,Murchie Alastair I. H.¹²

Affiliation:

1. Fudan University Pudong Medical Center, Pudong, and Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

2. Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China

Abstract

Class 1 integrons accumulate antibiotic resistance genes by site-specific recombination at aatI-1 sites. Captured genes are transcribed from a promoter located within the integron; for class 1 integrons, the first gene to be transcribed and translated normally encodes an aminoglycoside antibiotic resistance protein (either an acetyltransferase [AAC] or adenyltransferase [AAD]).

Funder

Natural Science Foundation China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00236-19

Reference66 articles.

1. Significance of antibiotics in the environment

2. The antibiotic resistome: the nexus of chemical and genetic diversity

3. Mutation and recombination in pathogen evolution: Relevance, methods and controversies