Increased Innate Immune Susceptibility in Hyperpigmented Bacteriophage-Resistant Mutants of Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Increased Innate Immune Susceptibility in Hyperpigmented Bacteriophage-Resistant Mutants of Pseudomonas aeruginosa

Published:2022-08-16 Issue:8 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Menon Nitasha D.¹²,Penziner Samuel³^ORCID,Montaño Elizabeth T.²,Zurich Raymond²,Pride David T.³⁴^ORCID,Nair Bipin G.¹⁵,Kumar Geetha B.¹⁵^ORCID,Nizet Victor²⁶^ORCID

Affiliation:

1. School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kerala, India

2. Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, UC San Diego, La Jolla, California, USA

3. Division of Infectious Diseases and Global Public Health, Department of Medicine, UC San Diego, La Jolla, California, USA

4. Department of Pathology, UC San Diego, La Jolla, California, USA

5. Tata Institute for Genetics and Society (TIGS), Bangalore, Karnataka, India

6. Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA

Abstract

Bacteriophage (phage) therapy is an alternative to traditional antibiotic treatments that is particularly important for multidrug-resistant pathogens, such as Pseudomonas aeruginosa . Unfortunately, phage resistance commonly arises during treatment as bacteria evolve to survive phage predation.

Funder

HHS | National Institutes of Health

University Grants Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00239-22

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2. Changing Rates of Chronic Pseudomonas aeruginosa Infections in Cystic Fibrosis: A Population-Based Cohort Study