AR-12 Exhibits Direct and Host-Targeted Antibacterial Activity toward Mycobacterium abscessus

Author:

Zhang Shaoyan1,Zou Yuzhen12,Guo Qi12,Chen Jianhui12,Xu Liyun1,Wan Xiaoyu1,Zhang Zhemin1,Li Bing1,Chu Haiqing13

Affiliation:

1. Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

2. Tongji University School of Medicine, Shanghai, China

3. Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

Abstract

Therapeutic options for Mycobacterium abscessus infections are extremely limited. New or repurposed drugs are needed. The anti- M. abscessus activity of AR-12 (OSU-03012), reported to express broad-spectrum antimicrobial effects, was investigated in vitro and in vivo . Antimicrobial susceptibility testing was performed on 194 clinical isolates. Minimum bactericidal concentration and time-kill kinetics assays were conducted to distinguish the bactericidal versus bacteriostatic activity of AR-12.

Funder

Natural Science Foundation of Shanghai Municipal Science and Technology Commission

Medical Guide Program of Shanghai Science and Technology Committee

New Frontier Technology Joint Project of Municipal Hospital, Shanghai Shenkang Hospital Development Center

Shanghai Municipal Health Committee Excellent Talents Training Program

General Project of Shanghai Municipal Health Committee

Project of Top Clinical Medicine Centers and Key Disciplines Construction in Shanghai

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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