Affiliation:
1. Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
2. Tongji University School of Medicine, Shanghai, China
3. Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
Abstract
Therapeutic options for
Mycobacterium abscessus
infections are extremely limited. New or repurposed drugs are needed. The anti-
M. abscessus
activity of AR-12 (OSU-03012), reported to express broad-spectrum antimicrobial effects, was investigated
in vitro
and
in vivo
. Antimicrobial susceptibility testing was performed on 194 clinical isolates. Minimum bactericidal concentration and time-kill kinetics assays were conducted to distinguish the bactericidal versus bacteriostatic activity of AR-12.
Funder
Natural Science Foundation of Shanghai Municipal Science and Technology Commission
Medical Guide Program of Shanghai Science and Technology Committee
New Frontier Technology Joint Project of Municipal Hospital, Shanghai Shenkang Hospital Development Center
Shanghai Municipal Health Committee Excellent Talents Training Program
General Project of Shanghai Municipal Health Committee
Project of Top Clinical Medicine Centers and Key Disciplines Construction in Shanghai
National Natural Science Foundation of China
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
19 articles.
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