Affiliation:
1. Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, USA
Abstract
Bacteria can be exposed to H
2
O
2
and NO· concurrently within phagosomes. In such multistress situations, bacteria could have evolved to simultaneously degrade both toxic metabolites or preferentially detoxify one over the other. Here, we found that simultaneous exposure to H
2
O
2
and NO· leads to prioritized detoxification, where detoxification of NO· is hampered until H
2
O
2
has been eliminated. This phenomenon resembles CCR, where bacteria consume one substrate over others in carbon source mixtures. Further experimentation revealed a central role for transcriptional regulation in the prioritization of H
2
O
2
over NO·, which is also important to CCR. This study suggests that regulatory scenarios observed in bacterial consumption of growth-promoting compound mixtures can be conserved in bacterial detoxification of toxic metabolite mixtures.
Funder
Helen Shipley Hunt *71
Forese Family Fund for Innovation
National Science Foundation
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
15 articles.
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