In Vivo Efficacy of a Chimeric Peptide Derived from the Conserved Region of the M Protein against Group C and G Streptococci-Reference-Cited by-同舟云学术

In Vivo Efficacy of a Chimeric Peptide Derived from the Conserved Region of the M Protein against Group C and G Streptococci

Published:2012-12 Issue:12 Volume:19 Page:1984-1987
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Nordström Therese¹,Malcolm Jessica¹,Magor Graham¹,Good Michael F.¹²,Batzloff Michael R.¹²

Affiliation:

1. Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia

2. Institute for Glycomics, Griffith University, Queensland, Australia

Abstract

ABSTRACT The J8 peptide from the conserved region of the M protein protects against group A streptococcus infections. In this study, we demonstrate that vaccination with a J8-containing formulation induces IgG that recognizes and binds group C and G streptococci. Moreover, this formulation has the potential to provide protection against infections caused by these organisms.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00140-12

Reference32 articles.

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5. Virulent human strains of group G streptococci express a C5a peptidase enzyme similar to that produced by group A streptococci

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