Regional Differences in Metronidazole Resistance and Increasing Clarithromycin Resistance among Helicobacter pylori Isolates from Japan

Author:

Kato Mototsugu1,Yamaoka Yoshio23,Kim Jae J.3,Reddy Rita3,Asaka Masahiro4,Kashima Kei2,Osato Michael S.3,El-Zaatari Fouad A. K.3,Graham David Y.3,Kwon Dong H.3

Affiliation:

1. Department of Endoscopy1 and

2. Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto,3 Japan, and

3. Department of Medicine, Baylor College of Medicine, Veterans Affairs Medical Center, Houston, Texas2

4. Third Department of Internal Medicine,4 Hokkaido University School of Medicine, Sapporo, and

Abstract

ABSTRACT The patterns of antibiotic resistance in Helicobacter pylori were assessed in two different regions in Japan. Overall, prevalences of resistance to metronidazole and clarithromycin were 12.4 and 12.9%, respectively. While there was no difference in clarithromycin resistance, the prevalence of metronidazole resistance was significantly higher in Kyoto (23.8%) than in Sapporo (8.1%). From 1996 to 1999, the prevalence of metronidazole resistance did not change but the prevalence of clarithromycin resistance doubled (from 9.1 to 18.7%).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference18 articles.

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2. Prevalence of Helicobacter pylori resistance to metronidazole, clarithromycin, amoxycillin, tetracycline and trovafloxacin in The Netherlands.;Debets-Ossenkopp Y. J.;J. Antimicrob. Chemother.,1999

3. Results of a multicentre European survey in 1991 of metronidazole resistance in Helicobacter pylori.;European Study Group on Antibiotic Susceptibility of Helicobacter pylori;Eur. J. Clin. Microbiol. Infect. Dis.,1992

4. Metronidazole resistance in Helicobacter pylori.;Glupczynski Y.;Lancet,1990

5. Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model.;Graham D. Y.;Gastroenterology,1997

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