Synergy between Trovafloxacin and Ceftriaxone against Penicillin-Resistant Pneumococci in the Rabbit Meningitis Model and In Vitro-Reference-Cited by-同舟云学术

Synergy between Trovafloxacin and Ceftriaxone against Penicillin-Resistant Pneumococci in the Rabbit Meningitis Model and In Vitro

Published:2000-08 Issue:8 Volume:44 Page:2179-2181
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cottagnoud Philippe¹,Acosta Fernando²,Cottagnoud Marianne²,Neftel Klaus²,Täuber Martin G.³

Affiliation:

1. Department of Internal Medicine, Inselspital,1

2. Department of Internal Medicine, Zieglerspital,2 and

3. Institute of Medical Microbiology, University of Bern,3 Bern, Switzerland

Abstract

ABSTRACT The bactericidal activities of monotherapy with trovafloxacin (−0.37 ± 0.15 Δlog 10 CFU/ml · h), vancomycin (−0.32 ± 0.12 Δlog 10 CFU/ml · h), and ceftriaxone (−0.36 ± 0.19 Δlog 10 CFU/ml · h) for the treatment of experimental meningitis in rabbits due to a clinical penicillin-resistant pneumococcal strain (MIC, 4 mg/liter) were similar. The combination of ceftriaxone with trovafloxacin considerably improved the killing rates (−0.67 ± 0.16 Δlog 10 CFU/ml · h) and was slightly superior to ceftriaxone with vancomycin (killing rate, −0.53 ± 0.22 Δlog 10 CFU/ml · h), the regimen most commonly used in clinical practice. In vitro, synergy was demonstrated between ceftriaxone and trovafloxacin by the checkerboard method (fractional inhibitory concentration index, 0.5) and by time-killing assays over 8 h.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.8.2179-2181.2000

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