Pyrrolidine Dithiocarbamate and Diethyldithiocarbamate Are Active against Growing and Nongrowing Persister Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Pyrrolidine Dithiocarbamate and Diethyldithiocarbamate Are Active against Growing and Nongrowing Persister Mycobacterium tuberculosis

Published:2007-12 Issue:12 Volume:51 Page:4495-4497
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Byrne Sean T.¹,Gu Peihua¹,Zhou Jiangbing¹,Denkin Steven M.¹,Chong Curtis²,Sullivan David¹,Liu Jun O.²,Zhang Ying¹

Affiliation:

1. Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, Maryland 21205

2. Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 N. Wolfe St., Baltimore, Maryland 21205

Abstract

ABSTRACT Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 μg/ml and 0.13 μg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00753-07

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