Eosinophils, but Not Eosinophil Peroxidase or Major Basic Protein, Are Important for Host Protection in Experimental Brugia pahangi Infection-Reference-Cited by-同舟云学术

Eosinophils, but Not Eosinophil Peroxidase or Major Basic Protein, Are Important for Host Protection in Experimental Brugia pahangi Infection

Published:2005-12 Issue:12 Volume:73 Page:8442-8443
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ramalingam Thirumalai¹,Porte Patricia¹,Lee James²,Rajan T. V.¹

Affiliation:

1. Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut

2. Mayo Clinic, Scottsdale, Arizona

Abstract

ABSTRACT The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.12.8442-8443.2005

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