Pathophysiological Manifestations in Mice Exposed to Anthrax Lethal Toxin-Reference-Cited by-同舟云学术

Pathophysiological Manifestations in Mice Exposed to Anthrax Lethal Toxin

Published:2005-10 Issue:10 Volume:73 Page:7006-7010
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Culley Nathan C.¹,Pinson David M.¹,Chakrabarty Anuradha²,Mayo Matthew S.³,LeVine Steven M.²

Affiliation:

1. Lab Animal Resources

2. Department of Molecular and Integrative Physiology

3. Department of Preventative Medicine and Public Health, University of Kansas Medical Center, Kansas City, Kansas 66160

Abstract

ABSTRACT Pathophysiological changes associated with anthrax lethal toxin included loss of plasma proteins, decreased platelet count, slower clotting times, fibrin deposits in tissue sections, and gross and histopathological evidence of hemorrhage. These findings suggest that blood vessel leakage and hemorrhage lead to disseminating intravascular coagulation and/or circulatory shock as an underlying pathophysiological mechanism.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.10.7006-7010.2005

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