Antibodies to Conserved Pneumococcal Antigens Correlate with, but Are Not Required for, Protection against Pneumococcal Colonization Induced by Prior Exposure in a Mouse Model-Reference-Cited by-同舟云学术

Antibodies to Conserved Pneumococcal Antigens Correlate with, but Are Not Required for, Protection against Pneumococcal Colonization Induced by Prior Exposure in a Mouse Model

Published:2005-10 Issue:10 Volume:73 Page:7043-7046
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Trzciński Krzysztof¹,Thompson Claudette¹,Malley Richard²,Lipsitch Marc¹

Affiliation:

1. Departments of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115

2. Division of Infectious Diseases, Department of Medicine, Children's Hospital, Boston, Massachusetts 02115

Abstract

ABSTRACT In mice following intranasal exposure to Streptococcus pneumoniae , protection against pneumococcal colonization was independent of antibody but dependent on CD4 + T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.10.7043-7046.2005

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