Affiliation:
1. Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
Abstract
Recombinant human interleukin-1 alpha augmented resistance of mice to microbial infections caused by Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Streptococcus pneumoniae, Salmonella typhimurium, and Candida albicans. The effective doses of interleukin-1 alpha ranged from 0.01 to 10 micrograms per mouse, depending on the infecting organism, route of administration, and challenge dose. Intravenous interleukin-1 alpha was, dose for dose, more effective than intravenous muramyl dipeptide and lentinan against the P. aeruginosa and K. pneumoniae infections. Augmentation by interleukin-1 alpha of resistance to infection was also observed in P. aeruginosa-infected mice in a state of cyclophosphamide-induced leucopenia. Interleukin-1 alpha may be useful for controlling obstinate infections not curable by antimicrobial agents alone.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference20 articles.
1. The synergistic contribution of macrophages and antibody to protection against Salmonella typhimurium during the early phase of infection;Akeda H.;J. Gen. Microbiol.,1981
2. Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs;Chedid L.;Proc. Natl. Acad. Sci. USA,1977
3. The role of interleukin-1 in neutrophil leukocyte emigration induced by endotoxin;Cybulski M. I.;Am. J. Pathol.,1986
4. Recombinant murine interleukin-la enhancement of nonspecific antibacterial resistance;Czuprynski C. J.;Infect. Immun.,1987
5. Induction of interleukin 1 by synthetic and naturally occurring muramyl peptides;Dinarello C. A.;Fed. Proc.,1986
Cited by
51 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献